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pentobarbital decreases amounts of panobinostat by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Sturdy CYP3A4 inducers can lower panobinostat degrees by ~70% and result in remedy failure.pentobarbital will lower the level or impact of atogepant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/W